蔡志强 教授

Email: zhqcai@cczu.edu.cn
个人荣誉
(1)江苏省“333高层次人才培养工程”第三层次培养对象
(2)2019年、2021年连续获得常州大学教学成果一等奖
(3)常州大学2014-2016年度优秀共产党员
(4)2020年获第二届常州大学教学名师培育对象
(5)2021年常州大学优秀教育工作者
(6)2022年常州大学师德标兵
(7)主编“十三五”江苏省高等学校重点教材《生物化学》
(8)主持江苏省一流课程《重组菌发酵生产γ-氨基丁酸虚拟仿真实验》
社会兼职
(1)江苏省生物技术协会常务理事
(2)省生物技术协会青年专家委员会副主任委员
(3)中国印染行业协会理事
研究方向
(1)生物降解
(2)有毒难降解工业废水生物处理、
(3)生物制品发酵
(4)酶工程
授课
(1)本科生课程:《微生物学》、《生物化学》
(2)研究生课程:《高级微生物学》
主持科研项目
(1)国家自然科学基金面上项目(11275033),主持人;
(2)江苏省自然科学基金面上项目(BK20151185),主持人;
(3)江苏省333人才培养工程;
(4)2015江苏省企业博士聚集计划;
(5)常州市社会发展项目(常州黑牡丹股份有限公司):高效硫氧化微生物菌剂的构建及其应用;
(6)光宝科技(常州)有限公司:天亮临床化学多项联合检测试剂试制评估;
(7)中国石化:高效硝化微生物菌剂的构建及其应用;
(8)江苏慧聚药业有限公司:生物法拆分手性环己烯甲酸制备S-CHCA;
(9)江苏悠恒生物有限公司:脂肪酶催化制备D-泛醇16迷粽榈酸单酯;
(10)江苏悠恒生物有限公司:果胶酶高产菌种选育及发酵生产酶制剂关键技术;
(11)茂名石化:高效硝化菌的中试应用研究;
(12)云汇环保科技南通有限公司:氯苯和苯乙烯气体生物除臭微生物菌剂的研发及应用;
(13)常州市合成生物揭榜挂帅项目:α-半乳糖苷酶的生物合成技术研发;
(14)上海开鸿环保科技有限公司:活性污泥减量化的复合生物技术研究
发表论文
(1)Teng Yuejie, Liu Tingting, Wang Tianxiang, Dong Yuanyuan, Ao Da, Yang Guanghua, Cai Zhiqiang*. Exopolygalacturonase Production from the Novel Strain Lichtheimia sp. UV-16 and Enzyme Hydrolysis Properties. Journal of agricultural and food chemistry. 2025. 73(1). 655-666.
(2)Zhu Ziming, Qin Zongmin, Yuan Bo, Cai Zhiqiang*, Qu Ge*, Sun Zhoutong*. Enhanced Production of Leucine–Leucine Dipeptide by Whole-Cell Catalysis. Journal of agricultural and food chemistry. 2025. 73(16). 9807-9816.
(3)Hong Tingting, Zhou Qi, Liu Yilian, Ji Yibing, Tan Songwen, Zhou Wenhu, Cai Zhiqiang*. Preparation of DNA nanoflower-modified capillary silica monoliths for chiral separation. Mikrochimica acta (1966). 2024. 191(10). 584.
(4)Hong Tingting, Zhou Qi, Liu Yilian, Guan Jiaqi, Zhou Wenhu, Tan Songwen, Cai Zhiqiang*. From individuals to families: design and application of self-similar chiral nanomaterials. Materials horizons. 2024. 11(17). 3975-3995.
(5)Guo J., Gao W., Zhang X., Pan W., Zhang X., Man Z., Cai Z*. Enhancing the thermostability and catalytic activity of Bacillus subtilis chitosanase by saturation mutagenesis of Lys242. Biotechnol J. 2024. 19(1). e2300010.
(6)Chen Long, Qu Ge, Cai Zhiqiang*, Yuan Bo*, Sun Zhoutong*. Synthesis of a sacubitril precursor via the construction of one-pot chemoenzymatic cascades. Catalysis science & technology. 2024. 14(10). 2817-2824.
(7)Chen Ke, Zhang Jingyun, Liu Xing, Zhang Peiyuan, Yue Wenlong, Cai Zhiqiang*. High Molecular Weight α-Galactosidase from the Novel Strain Aspergillus sp. D-23 and Its Hydrolysis Performance. Processes. 2023. 11(1). 255.
(8)Hong T., Liu X., Ji Y., Tan S., Cai Z*. Construction of chiral capillary electrochromatography microsystems based on Aspergillus sp. CM96. Mikrochim Acta. 2023. 190(9). 357.
(9)Hong Tingting, Zhou Wenhu, Tan Songwen, Cai Zhiqiang*. A cooperation tale of biomolecules and nanomaterials in nanoscale chiral sensing and separation. Nanoscale horizons. 2023. 8(11). 1158-1485.
(10)Jing Guo, Wenjun Gao, Yi Wang, Kepan Xu, Wen Luo, Tingting Hong, Zhiqiang Cai*. Enhancing Enzyme Activity and Thermostability of Bacillus amyloliquefaciens Chitosanase BaCsn46A Through Saturation Mutagenesis at Ser196. Current microbiology. 2023. 80(5). 180.
(11)Jin Yi, Tomeh Mhd Anas, Zhang Peng, Su Mingzhu, Zhao Xiubo*, Cai Zhiqiang*. Microfluidic fabrication of photo-responsive Ansamitocin P-3 loaded liposomes for the treatment of breast cancer. Nanoscale. 2023. 15(8). 378-3795.
(12)Hong Tingting, Liu Xing, Zhou Qi, Liu Yilian, Guo Jing, Zhou Wenhu, Tan Songwen, Cai Zhiqiang*. What the Microscale Systems “See” In Biological Assemblies: Cells and Viruses? Analytical chemistry (Washington). 2022. 94(1). 59-74
(13)Guo Jing, Wang Yi, Gao Wenjun, Wang Xinrou, Gao Xin, Man Zaiwei, Cai Zhiqiang*, Qing Qing. Gene Cloning, Functional Expression, and Characterization of a Novel GH46 Chitosanase from Streptomyces avermitilis (SaCsn46A). Applied biochemistry and biotechnology. 2022. 194(2). 813-826.
(14)Guo Jing, Wu Xingke, Liu Suyu, Zhang Yu, Cai Zhiqiang*. Screening of three ammonia-oxidizing bacteria and construction of compounding agent CCZU C6 in high-efficiency ammonia-oxidizing. Journal of water process engineering. 2021. 40. 101862
(15)Gu Yiming, Zhu Xiaolin, Yu Wenjia, Zhong Wenya, Guo Jing, Cai Zhiqiang*. Oxidization and biodegradation of sulfur black by a newly isolated strain Acinetobacter sp. DS-9. Desalination and water treatment. 2021. 227. 321-329.
(16)Man Zaiwei, Guo Jing, Zhang Yingyang, Cai Zhiqiang*. Regulation of intracellular ATP supply and its application in industrial biotechnology. Critical reviews in biotechnology. 2020. 40(8). 1151-1162.
(17)Zhang Jingyun, Chen Ke, Liu Xing, Chen Huiling, Cai Zhiqiang*. Treatment of High-Ammonia-Nitrogen Wastewater with Immobilized Ammonia-Oxidizing Bacteria Alcaligenes sp. TD-94 and Paracoccus sp. TD-10. Processes. 2023. 11(3). 926
(18)Chen Huiling, Wan Meimei, Liu Yang, Yang Guanghua, Cai Zhiqiang*. Solid-State Fermentation of Hyperactive Pectinase by the Novel Strain Aspergillus sp. CM96. Processes. 2024. 12(3). 615.
(19)Guan Zhipeng, Wang Yating, Chen Wentao, Li Yanchen, Yue Wenlong, Cai Zhiqiang*. Biodecolorization and Biodegradation of Sulfur Black by the Strain Aspergillus sp. DS-28. Processes. 2024. 12(9). 1818.
(20)Zhu Xiaolin, Hou Kaiyao, Zheng Peiyang, Zhong Wenya, Guo Jing, Zhao Xiyue, Hong Tingting, Cai Zhiqiang*, Li Weiguo. Improvement of Biosynthetic Ansamitocin P-3 Production Based on Oxygen-Vector Screening and Metabonomics Analysis. Evidence-based complementary and alternative medicine. 2022. 2022. 1-11.
(21)吴兴可, 祁荃, 卞婷婷, 刘苏煜, 谷艺明, 郭静, 蔡志强*. 珍贵橙色束丝放线菌发酵产安丝菌素P-3的分离纯化工艺优化. 化工进展. 2020. 39(3). 1122-1128.
(22)仲文雅, 俞汶佳, 谷艺明, 郭静, 樊博, 蔡志强*. 生物合成安丝菌素的研究进展. 化工进展. 2021. 40(2). 990-997.
(23)金毅, 苏明珠, 郭静, 吕松伟, 蔡志强*. 微流控流体动力聚焦技术制备的脂质体及靶向乳腺癌的新策略. 中国医药工业杂志. 2022. 53(6). 801-810.
(24)罗雯, 徐珂盼, 王怡, 蔡志强*. 果胶酶生产菌株的筛选、发酵优化及其酶学性质研究 [J]. 食品科技, 2022, 47 (04): 6-13.
(25)陈可,刘星,张景韵,蔡志强*. 生物合成α-半乳糖苷酶的研究进展 [J]. 中国酿造, 2023, 42 (01): 1-8.
代表性专利
(1)蔡志强 等,一种黑曲霉固态发酵产果胶酶的方法,国内发明专利,申请号:202111062610.0;
(2)蔡志强 等,一种氨氧化复合菌剂及其制备方法和应用,国内发明专利,申请号:202110774387.6;
(3)蔡志强,张宇等,一种同步纯化脂肪酶、酸性蛋白酶和α-淀粉酶的方法, 国内发明专利,申请号:201910941211.8;
(4)蔡志强,张宇等,一种高产脂肪酶酶活菌株的筛选方法, 国内发明专利,申请号:201910980977.7;
(5)蔡志强,殷鹏等,一株高效硫氧化菌在含硫化黑废水处理中的应用,国内发明专利,申请号:201811000737.8;
(6)蔡志强,周少敏等,一种安丝菌素P-3的提取与分离纯化方法,国内发明专利,申请号:201810033155.3;
(7)蔡志强,杨广花,朱孝霖,王国平.一种脂肪酶催化制备肉豆蔻醇丝氨酸酯的方法. 国内发明专利,发明专利证号:ZL 201210321681.2.
(8)蔡志强,朱孝霖,杨广花,王国平,赵希岳.一种脂肪酶催化制备D-泛醇16醚棕榈酸单酯的方法,发明专利,公开号:ZL 201210321618.9.
(9)李尔炀,蔡志强,杨广花,李亮.芽胞杆菌工程菌及其在油藏示踪和采油的应用. 国内发明专利,发明专利证号:ZL 201010235088.7;
(10)蔡志强 等. 一种固定化脂肪酶催化合成L-丝氨酸十八醇酯的方法,发明专利,2013,中国,公开号:CN 103320479 A;
(11)蔡志强 等. 万古霉素菌株及其发酵产万古霉素的方法,发明专利,2012,中国,公开号:CN 102899268 A;
(12)蔡志强 等. 一株高温芽孢杆菌制备脂肽类生物表面活性剂的方法,发明专利,2011,中国,公开号: CN 102399847 A;
专著
(1)蔡志强主编,《生物化学》,“十三五”江苏省高等学校重点教材,化学工业出版社.
(2)蔡志强主编. 《生物化学》, 化学工业出版社, 2010.
(3)王利群(主编),蔡志强(副主编).《生物技术》, 东南大学出版社, 2010.